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Manufacturing Associate II – III

Job Code 201706


The Manufacturing Associate is responsible for supporting manufacturing operations by working as an operator in all aspects of plasmid DNA manufacturing, including fermentation, lysis, and chromatography processes. This position requires strict adherence to SOPs and cGMP regulations, the ability to accurately complete process associated documentation, perform calculations and physical tasks associated with large scale bioprocess manufacturing.

Specific Responsibilities

  • Operate large scale fermentor, centrifuge, depth filtration, ultrafiltration/diafiltration (UF/DF), and chromatography skids/columns
  • Completes and maintains documentation related to assigned work, including batch records and logbooks
  • Assemble and prepare equipment for production
  • Dispensing of buffer preparation components
  • Perform media and buffer preparation activates
  • Sterile filtration and filter integrity testing
  • Clean in Place (CIP) and Steam in Place (SIP) of tanks using automated systems
  • Clean out of Place (COP)/Glasswash of misc. parts and equipment
  • Routine maintenance of analytical equipment including pH and conductivity meters, scales, benchtop centrifuges, pumps, and general equipment
  • Expected duties also include planning and executing safe and efficient process operations, Good Documentation Practices, timely communication of deviations, incidents and/or safety concerns and all relevant housekeeping duties to ensure the work areas are kept to a high level of cleanliness and inspection readiness

Job Knowledge and Experience

The ideal candidate will possess:

  • Experience using large-scale processing equipment: stirred-tank bioreactors, continuous-flow centrifuges, ultrafiltration skids, process tanks, chromatography systems, and automated CIP/SIP systems
  • Experience working in a cGMP cleanroom environment, including familiarity with cGMP documentation practices and process deviation investigations
  • Mechanical aptitude, troubleshooting, and problem solving ability
  • The ability to communicate clearly and precisely, both orally and in writing
  • Confidence, initiative, strong interpersonal and collaborative skills, and good personal organization skills.
  • Candidate must be able to lift up to 50 pounds
  • Ability to independently identify problems and effectively offer solutions to problems
  • Ability to work on multiple tasks simultaneously and meet project deadlines
  • Experience working on cross-functional teams and a commitment to working in a fast-paced environment


Bachelor’s degree in Natural Sciences or related discipline with 3 - 8 years of experience in a cGMP manufacturing pharmaceutical/biotechnology environment.

 *Candidates experience and education will determine job title.


Vical's Equal Employment Opportunity Policy

Vical is committed to a policy of equal employment opportunity. In keeping with our policy, Vical will recruit, hire, train and promote into all job titles the most qualified individuals, without regard for race, color, religion, sex, sexual orientation, national origin, ancestry, age, marital status, veteran status, disability, medical condition, usage of family and medical leave, or usage of pregnancy disability leave.

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To apply, please reference the specific job code in your cover letter and submit with your C.V. or résumé to Human Resources:

By email:
By fax: 858-646-1154
By mail:
Human Resources
Vical Incorporated
10390 Pacific Center Court
San Diego, CA 92121-4340
P. 858 646 1100 10390 Pacific Center Court, San Diego, California 92121
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